NMR


Head of department

Lionel ALLOUCHE
email : allouche@unistra.fr


Staff

Maurice COPPE
email : mcoppe@unistra.fr

Bruno VINCENT
email : bvincent@unistra.fr

Cyril ANTHEAUME
email : antheaume@unistra.fr


Contact

Phone: +33.(0)3.68.85.17.23
Fax: +33.(0)3.68.85.17.24
Location: Faculty of Chemistry  (basement)

Address:
Service de RMN
Fédération de chimie Le Bel – FR2010
BP 296R8
1, rue Blaise Pascal
F-67008 STRASBOURG Cedex


Focuses

Main activities

Analysis and expertise in NMR: High-level equipment, know-how and expertise in NMR make it possible to offer molecular structural analyzes with a strong impact in chemistry, biology and pharmacy.

Training and teaching in NMR

The NMR Service offers training to students, PhD students, post-docs and researchers in the field of NMR solutions.
The service also offers internships as part of the ongoing training of the University of Strasbourg (academic and private law).

Link:
https://sfc.unistra.fr/formations/chimie-bio_-_techniques-danalyses-physico-chimiques-et-biologiques_-_la-rmn-en-chimie-et-en-biologie_-_851/


Access to instruments

Access to the spectrometers is via an online booking site https://rmn.u-strasbg.fr or a request via an electronic form.


Analysis request form

Complete the request form and drop it to the NMR service.


Instruments

The instrumental park of the NMR service is composed of 6 BRUKER spectrometers for the analysis of the solutions.

  • Bruker Avance III Spectrometer – 600 MHz
    Inverse 1H-X probe 5 mm (with 31P <X <15N)
    X-1H-19F probe 5 mm (with 31P <X <103Rh)
    Static probe 1H-19F diffusion 5 mm (G max = 500 G / cm)
    1H-X reverse diffusion 5 mm probe (G max = 300 G / cm and with 31P <X <15N)
  • Bruker Avance III spectrometer – 500 MHz
    Cryo-Probe Hélium X-1H 5mm (with 31P < X < 15N)
    Automatic sample changer
  • Bruker Avance II Spectrometer – 500 MHz
    Cryo-Probe Hélium 13C-1H 5mm
    Automatic sample changer
  • Bruker Avance III Spectrometer – 400 MHz
    Inverse 1H-X 5 mm probe (with 31P < X < 15N)
    Self-service access
    (http://rmn.u-strasbg.fr/)
  • Bruker Avance I Spectrometer – 300 MHz
    31P-1H 5mm probe
    Self-service access
    (http://rmn.u-strasbg.fr/)
  • Bruker Avance III Spectrometer – 300 MHz
    X-1H-19F 5 mm probe (with 31P < X < 15N)
    Automatic sample changer
  • Micro-viscometer
    Dynamic viscosity measurement for 1 mL samples
  • Density Meter

Instruments in photos…


Benefits

The NMR experiments below are feasible in the NMR service:

  • Multi-nuclei (1H, 13C, 31P, 15N, 2H, 19F, 109Ag, 199Hg, 27Al, 29Si, 11B, 195Pt, etc.)
  • Polarization transfer and editing
  • Selective irradiation: NOE difference, homo-decoupling, solvent removal, PURESHIFT
  • Homo-nuclear correlations: COSY, NOESY, ROESY, TOCSY, EXSY, INADEQUATE
  • Hetero-nuclear correlations: HMQC, HSQC, HMBC, HOESY, ADEQUATE, H2BC
  • Combined experiences: HSQC-TOCSY, HSQC-NOESY
  • Molecular dynamics measurements
  • reaction kinetic measurements
  • Quantification methods
  • Ligand-inhibitor interaction: STD, WaterLOGSY
  • Diffusion coefficient measurements: DOSY 1H, 19F, 31P
  • Coupling constant measurements: selective J-RES 1H-13C, HECADE 1H-13C, G-SERF, X.E.COSY, XLOC

Data processing with « Mnova»


Prices

Experiments are billed relative to the time of use of the spectrometers (see the rate table UNISTRA 2018 / addendum)